セフォタキシムのビタミン剤含有水溶液中での光安定性

概要

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We investigated the photo-stability of some third-generation cephalosporins in aqueous solution containing such vitamins, as vitamin B_1, B_2, B_6 , C, K_2, and panthenol. Although cephem derivatives are stable in aqueous solution without vitamins during 4 hours of sun light irradiation at room temperature, sun light irradiation for 2 hrs did cause the photo-degradation of cefotaxime (CTX) in aqueous solution (2 mg/ml) containing flavin adenine dinucleotide (FAD, VB_2 derivative)or pyridoxal phosphate(PAL-P. VB_6 derivative), while. in addition. the residual rate of CTX in the solution also decreased to less than 70%. Similarly, the residual rate of CTX in a solution of benzophenon, a triplet photosensitizer. also rapidly decreased during sun light irradiation. Sun light irradiation also decreased the residual rates of other cephalosporins with an oxyimino group at position 7 under the same conditions. The main degradation product was identified as an anti-isomer of CTX. These above described findings thus suggest that FAD and PAL-P may act as photosensitizers in the sun light-induced degradation of cephalosporins.
日本医療薬学会の論文
1996-12-10