Influence of beta-blocker on equilibrium disturbance after alcohol ingestion.

概要

論文の詳細を見る
This study was undertaken to assess the interaction between alcohol and betablocker onthe body equilibrium function. Six healthy male subjects ingested alcohol (1 ml/kg) within10 min after administration of a beta-blocker. The equilibrium disturbance following ingestion of alcohol was evaluated as an increase in area of the center of gravity (ACG), because the ACG after alcohol ingestion had been shown to increase in parallel with theblood concentration of alcohol. Either treatment with metoprolol (40 mg) or pindolol (10mg) augmented the increase in ACG by alcohol, but atenolol (50 mg) did not affect it.Alcohol induced decline in critical flicker fusion (CFF) threshold. The decline in CFFinduced by alcohol was also augmented after administration of metoprolol and pindolol, butnot atenolol. Each beta-blocker itself had no effect on ACG nor CFF. Blood levels ofalcohol were unaffected by treatments with beta-blockers, though metoprolol tended toshorten the elimination of alcohol. These results indicated that lipophilic beta-blockers, metoprolol and pindolol, augmented the alcohol-induced equilibrium disturbance, conceivablyby their interaction with alcohol at brain. In contrast, atenolol, a hydrophilic betablocker, did not influence the effect of alcohol on the central nervous system.
一般社団法人日本臨床薬理学会の論文