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Following the first investigation of single dosage of "MAPIN" T 5 in healthy subjects (First report), the effect of the drug was tested by successive daily administration for 7 days in the amount of 20 mg per day (2×10 mg) to 6 male and healthy subjects. Their age was 24.8 years on the average.<BR>The test comprised "cardiac function test", various laboratory tests and observation of tolerance of the drug.<BR>1. No subjective trouble attending the intake of the drug was observed except for a case where a nausea occurred 1. 5 hours after the drug administration. This, however, was considered to due to an overeating the day before and not to the drug itself.2. Regarding "cardiac function test", among "systolic time intervals" significant lowering of isovolumetric contraction time and preejection period/ejection time and increase of ejection fraction were observed one hour after the drug intake. These findings are indicative of the existence of cardiotonic effects of "MAPIN" after its oral intake.<BR>3. Among the laboratory tests nothing was to be noted except some elevation in GOT and GP T values of blood though both were within normal limits. This is considered of minor importance but further observation in a more prolonged and continuous administration might be desirable.<BR>4. Detailed study for pharmacokinetics could not be performed this time because the quantitative estimation of concentration of "MAPIN" in the blood was not possible. However the serum samples were preserved in an appropriate refrigerator for future analysis and the results of such analysis in the future will elucidate the fate of the drug in the body.
一般社団法人日本臨床薬理学会の論文

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