:Comparison of Nadolol and Propranolol

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Groups of 6 healthy male subjects were respectively given single oral doses of placebo, nadolol, 20, 40 or 80 mg (Corgard®, Squibb, England), or propranolol, 20 or 40 mg (Inderal®, ICI, Japan). Exercise tests using a bicycle ergometer were performed with the subjects in supine position before and at 1, 2, 4, 6, 8, 12 and 24 hours after administration.<BR>The double products at rest and during exercise were most markedly inhibited at 2 hours after administration of either nadolol or propranolol. Subsequently, the action of propranolol rapidly diminished, whereas nadolol, at each dose level, showed significant inhibion.<BR>The elimination half-lives of unchanged compounds in the blood were 14.0 hours for nadolol at 40 mg and 3.8 hours for propranolol at 40 mg, corresponding well with their pharmacological half-lives (17.9 hours and 7.2 hours, respectively).<BR>Hemodynamic parameters, such as cardiac index (CI) and stroke index (SI), were most markedly inhibited at 2 hours after administration of nadolol or propranolol.<BR>Hemodynamic parameters, such as cardiac index (CI) and stroke index (SI), were most markedly inhibited at 2 hours after administration of nadolol or propranolol.
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