Studies on transdermal absorption of isosorbide dinitrate tape.

概要

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With the object of obtaining information about factors influencing the effect of isosorbide dinitrate (ISDN) tape (Frandol tape®), the effect of bathing, application site, water content of the corneal layer of epidermis, tissue blood flow and age on the plasma ISDN concentration was studied by applying Frandol tape® to healthy male volunteers, and the following results were obtained.<BR>1. The plasma ISDN concentration was enhanced transiently upon bathing.<BR>2. A higher plasma ISDN concentration was obtained when the tape was applied on the back or leg than on the breast.<BR>3. There was no relationship between plasma ISDN concentration and water content of the corneal layer or on the tissue blood flow.<BR>4. High plasma ISDN concentrations were exhibited in younig men, but were not Significant.
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