フェニトイン,バルプロ酸,サリチル酸のin vitro血清蛋白結合における相互作用

概要

論文の詳細を見る
Drug interactions on protein binding between phenytoin (PHT), valproic acid (VPA) and salicylic acid (SA) were studied by using human serum, when VPA and SA were added to serum concomitantly, percentage of unbound concentration (free percent) of both drugs were increased significantly than that of VPA or SA alone respectively. When PHT and VPA were added similarly, free percent of PHT was increased significantly than that of PHT alone, but that of VPA was not changed clearly. On the other hand, in the case of PHT and SA were added in the same way, free percent of both drugs were not changed significantly. The concomitant addition of PHT, VPT and SA to serum resulted in a significant increase of free percent of all the drugs compared to their respective controls and the degrees of their respective increases were similar to those that were shown by the concomitant addition of PHT and VPA or VPA and SA. From these results, it was considered that the concomitant clinical use of PHT, VPA and SA might strengthen the pharmacological effects of all these drugs.
日本医療薬学会の論文
1989-03-20