アスピリン喘息患者に対する非ステロイド性消炎鎮痛剤負荷例について

概要

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Non-steroidal antiinflammatory drug (NSAID) challenge tests were given to patient with aspirin-induced asthma (AIA) to observe the changes of the forced expiratory volume in one second (FEV_<1-0>) between before and after challenges. PL granules for children (PL[○!R]) as acid NSAID, that consists of 45 mg salicylamide, 25 mg acetaminophen and 10 mg anhydrous caffein per gram, meplrizole and tiaramide hydrochloride as basic NSAID, and syoseiryuto as Chinese traditional medicine were used. FEV_<1-0> was measured before and several times after oral challenges of NSAIDs and syoseiryuto, and decrease of more than 20% of the initial value (basal value) was defined as a positive response. PL, Acid NSAID, showed clear positive response 30 min after challenge, but basic NSAID mepirizole and Chinese traditional medicine syoseiryuto showed negative response. On the other hand, tiaramide hydrochloride, that is also basic NSAID, showed positive response when administered 40 mg although negative in a dose of 20mg. These results suggest that the administration of NSAID to patient with AIA, even in a case of basic NSAID, must be done carefully, and it should be carried out as challenge tests in those cases.
日本医療薬学会の論文