補体活性化に対する蛋白分解酵素阻害剤の抑制効果

概要

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Inhibitory effects of various protease inhibitors on complement-hemolysis were investigated in vitro. In the hemolytic action system for classical pathway, sensitized sheep erythrocytes at a concentration of 2.0×l0^8 cells/0.2ml and diluted normal human serum were used, and in alternative pathway, unsensitized rabbit erythrocytes at a concentration of 1×10^8 cells/0.4ml and diluted normal human serum were used. Gabexate mesilate, camostat mesilate and nafamostat mesilate inhibited complement-hemolysis including both the classical and alternative pathways, but aprotinin and urinastatin did not inhibited at 100 fold concentration of usual dose. Among these protease inhibitors, nafamostat mesilate strongly inhibited complement-hemolysis. With usual dose, nafamostat mesilate obviously indicated anti-complement activity.
日本医療薬学会の論文
1988-10-20