1 自由細胞型腫瘍細胞 (TS細胞) における myc 遺伝子群の発現 (第434回大阪歯科学会例会)

概要

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We studied the rearrangement and amplification of the myc gene family in rat ascites tumor (TS)cells at the 2,918 th passage after successive transplantation in Spraque-Dawley rats. Southern-blotting analysis showed that TS cells presented a different pattern from normal rat spleen cells in c-myc probe hybridization, indicating that the molecular weight of c-myc fragments in TS cells differed from that in normal cells. This implies that the c-myc in TS cells had been rearranged. Slot-blotting analysis showed that the myc genes in TS cells had the same intensity as those in the control, indicating an absence of amplification of the myc gene family in TS cells. These observations may contribute to our understanding of the characteristics of gene expression in TS cells.
大阪歯科学会の論文
1994-04-25