4 老化促進モデルマウスの中枢神経系組織におけるヒアルロン酸およびコンドロイチン硫酸糖鎖の加齢変化 (例会抄録(第422回))

概要

論文の詳細を見る
Age-related changes in cerebral hyaluronic acid (HA) and chondroitin sulfate (CS) in senescence-ac-celerated mice (SAM-P/8//Odu, P substrain) were determined and compared with those of controls (SAM-R/1//Odu, R substrain). The CS chain consisted mainly of ΔDi-4S, with ΔDi-0S and ΔDi-6S as minor components for all ages of both substrains. The amount of each of the unsaturated disaccharides was higher in the R substrain than in the P substrain mice for all ages. These results indicate that the qualitative and quantitative changes in cerebral CS and HA of the P substrain mice were already expressed at 7 weeks of age and may cause the physiological and functional alterations associated with senescence in the central nervous system.
大阪歯科学会の論文
1993-02-25