新規な割線入りフィルムコーティング錠の分割性評価

概要

論文の詳細を見る
The usefulness and uniformity of division for three types of tablets (Ul9D9. U8D9 and U2D9) were investigated to design a novel film-coated scored tablet. which can be divided by pressure regardless of the side with the score and the presence of packaging. were evaluated by pharmacists. volunteers and elderly patients. The results obtained are as follows : l. Though the usefulness of division,which deteriorated with the presence of~ packaging. was affected by the dividing method. the overall evaluations of Ul9D9 and U8D9 were superior to that of' U2D9 . 2. Ul9D9 showed a uniform division regardless of the subject, dividing method and presence of packaing when dividing one tablet. when dividing of one packaged sheet ( 10 tablets). the coefficient of variation of the divided tablet weight for Ul9D9 and U8D9 was smaller than that for U2D9. 3. From the above results. Ul9D9 was found to be a film-coated scored tablet that was easy to divide and also demonstrated a greater uniformity of division.
日本医療薬学会の論文
1999-06-10