Modification of Liposomes by Addition of HCO60. II. Encapsulation of Doxorubicin into Liposomes Containing HCO60

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概要

• 論文の詳細を見る

• The efficiency of encapsulation of doxorubicin (DOX) into liposomes containing HCO60 was studied. Empty egg phosphatidylcholine (PC) liposomes containing various amounts of HCO60 were passed through a polycarbonate membrane filter (0.1 μm). Closed vesicles were formed even with liposomes containing 90 wt% HCO60. DOX was encapsulated efficiently (more than 1 mg DOX/8 mg lipids) using a pH-gradient method. HCO60 accelerated the leakage of DOX from liposomes into phosphate buffer at temperatures above 25℃. HCO60 suppressed the leakage of DOX from egg PC/cholesterol (7/3,w/w) liposomes into phosphate buffer containing 50% fetal bovine serum (FBS). Studies on the interaction between liposomes and serum components using zeta potential and turbidity suggest that HCO60 prevents the liposomes from interacting with serum components.

• 公益社団法人日本薬学会の論文
• 1993-10-15

著者

• 加藤 泰己

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 細川 俊仁

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 早川 栄治

  Pharmaceutical Research Laboratories, Kyowa Kakko Kogyo Co., Ltd.,

• 伊藤 邦雄

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 伊藤 邦雄

  協和醗酵工業株式会社医薬総合研究所製剤研究所

• 早川 栄治

  協和発酵工業株式会社医薬研究所

• 伊藤 邦雄

  Pharmaceutical Institute Tohoku University

• 早川 栄治

  協和醗酵工業株式会社医薬総合研究所製剤研究所

• 早川 栄治

  協和発酵工業株式会社

• 加藤 泰己

  協和醗酵工業株式会社医薬総合研究所製剤研究所

• 大久保 雄一

  Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• 細川 俊仁

  Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• 大久保 雄一

  Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

関連論文

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• Modification of Liposomes by Addition of HCO60. II. Encapsulation of Doxorubicin into Liposomes Containing HCO60
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• 医薬と高分子
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