Studies on the Dissolution Behavior of Doxorubicin Hydrochloride Freeze-Dried Product

概要

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Doxorubicin hydrochloride interacts with various metal salts in aqueous solution and is associated with the prolongation of dissolution time. When a doxorubicin hydrochloride freeze-dried product was dissolved with isotonic sodium chloride solution, several small jelly-like spheres appeared locally. The futher addition of NaCl promoted the gel formation and the whole solution turned into a viscous liquid.A diffusion experiment using filter paper and X-ray microanalyzer analysis indicated that the highly viscous structure, which was the cause of the prolongation of dissolution time, was formed on the surface of the small spheres by the interaction of doxorubicin with NaCl.We found that methyl parahydroxybenzoate L-phenyl alaninem, urea, and citric acid, etc. had a shortening effect on the dissolution time of the doxorubicin hydrochloride freeze-dried product, and moreover, these additives reduced the viscosity of the aqueous solution of doxorubicin hydrochloride enhanced by the addition of NaCl.
公益社団法人日本薬学会の論文
1990-12-25