N^2-アセチル-L-グルタミンアルミニウム錯体の物理化学的性質コンドロイチン硫酸との相互作用

概要

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In recent years there have been numerous reports about N^2-acetyl-L-glutamine aluminum complex (KW-110) which has been evaluated as an anti-ulcer drug, especially as a gastric mucous membrane protective one. In order to elucidate the characteristic of this drug, the interaction of various aluminum compounds, such as aluminum chloride, aluminum potassium sulfate and KW-110,with chondroitin sulfate A, one of the most important components of gastric mucous membrane, was investigated by the equilibrium dialysis method in aqueous solutions at 37° and 22°. The result are as follows ; there are two binding sites on chondroitin sulfate A for aluminum of KW-110. One has about 1.5 binding sites of relatively strong affinity (ΔF_1=-6 kcal/mol). The other has about 3.5 binding sites of relatively weak affinity (ΔF_2=-3 kcal/mol). On the other hand, there is only one binding sites on chondroitin sulfate A for aluminum ions of inorganic aluminum compounds. In the latter case, the binding sites on chondroitin sulfate A correspond to the first one for KW-110,and this kind of binding is due to the electrostatic force. Therefore it is assumed that the second one for KW-110 is characteristic of aluminum derived from KW-110.
社団法人日本薬学会の論文
1977-07-25