指定発言心身疾患と免疫性変化(ストレスと免疫第29回日本心身医学会総会 1988年5月28日/於東京)

概要

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We studied the immunological consequences of patients with psychosomatic disorders. Eating Disorder (ED) patients who are under malnutrition and psychological stress, have clinically shown a low incidence of infection.Ten patients with ED were compared with normal weight control, regarding their natural killer cell activity (NK activity) in blood samples. The ED patients did not show a statistically significant decrease in NK activity, and there were no correlations between the NK activity and weight loss, visceral protein indicator (S-Albumin).Fifteen patients with ED were studied for cell mediated immunity in terms of lymphocyte transformation responses (LTR) to T cell mitogen (PHA, ConA), B cell mitogen (PWN). The mitogen responsiveness was preserved untill weight loss and physical sevevity were far advanced.The LT responsibilities to T cell mitogen (PHA, Con A) in 8 depressive patients and 9 somatoform disorder patients shoswed a low tendency, although clinical data were conflicting.In the depressive patients who have high cortisol secretions, the LT responsibilities to mitogen were not correlated with hypercortisolnemia.
1989-02-01