CROSS RESISTANCE AGAINST CHALLENGE INFECTION IN MICE INFECTED WITH TRICHINELLA SPIRALIS OR T. PSEUDOSPIRALIS

概要

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Worm recovery from the small intestine was carried out in ICR mice infected with either Trichinella spiralis or T. pseudospiralis and then homologously or heterologously challenged 14 or 42 days after the primary infection. Significantly less worms were recovered from challenge infections as compared to the naive positive controls. Less worms were expelled from mice challenged on day 42 than on day 14 after the primary infection. Significantly more worms were retained in the groups of mice primarily infected with T. spiralis and then challenged with T. pseudospiralis as compared to the other three challenged groups. This was observed in both the groups of mice challenged on days 14 and 42 after the primary infection. A correlation between the number of worms retained in each mouse and the number of intestinal mucosal mast cells in the individual mouse was observed. No significant difference was observed in the number of muscle larvae recovered by digestion from among the challenge and the control groups of infected mice. However, in histopathological examination of T. spiralis infected mice challenged with T. pseudospiralis on day 42 after primary infection, almost no T. pseudospiralis larvae were observed in the muscle but when the infection protocol was reversed, the muscle section showed about 40% T. spiralis larvae and 60% T. pseudospiralis larvae.
北海道大学の論文
1987-04-30