STUDIES ON ECHINOCOCCOSIS XVI : EFFECTS OF DRUGS UPON SCOLICES AND DAUGHTER CYSTS OF ECHINOCOCCUS MULTILOCULARIS IN VITRO
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概要
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The morphological changes of scolices and daughter cysts of Echinococcus multilocularis obtained experimentally from infected cotton rats were investigated cytopathologically by use of routine and phase contrast microscopes and supravital staining with neutral red and Janus green. Degenerative changes were recognized distinctly in parenchymal cells of scolices and germinal cells of daughter cyst. The regressive change was accepted as an indication of degeneration of the scolices and daughter cysts in addition to the abnormal changes of themselves. The scolices and daughter cysts were incubated in the medium consisting essentially of 20% bovine serum in medium 199 to which-methyridine, diethylcarbamazine citrate, chloroquine-diphosphate, dl-cupric methionate, sodium antimony-III-biscatechol-2,4-sodium disulfate, sodium antimonyl tartrate and dithiazanine iodide-were added at the rates of 10,40 and 100γ per ml. These scolices and daughter cysts were investigated for 10 days and following results were obtained. Sodium antimonyl tartrate, sodium antimony-III-biscatechol-2,4-sodium disulfonate and dithiazanine iodide manifested the comparatively stronger effects, the decrease of effects was recognized in order as dl-cupric methionate, chloroquine-diphosphate and diethylcarbamazine and methyridine showed the lowest effect, and the highest rate of vesiculated scolices was recognized in the medium with methyridine.
- 北海道大学の論文
著者
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OHBAYASHI Masashi
Department of Parasitology, Faculty of Veterinary Medicine, Hokkaido University
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Ohbayashi Masashi
Department Of Parasitology Faculty Of Veterinary Medicine Hokkaido University
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Ohbayashi Masashi
Laboratory Of Veterinary Pathology Faculty Of Veterinary Medicine Hokkaido University
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Yamashita Jiro
Department Of Parasitology Faculty Of Veterinary Medicine Hokkaido University
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SAKAMOTO Tsukasa
Department of Parasitology Faculty of Veterinary Medicine Hokkaido University
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ORIHARA Miyoji
Department of Parasitology Faculty of Veterinary Medicine Hokkaido University
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Sakamoto Tsukasa
Department Of Internal Veterinary Medicine Faculty Of Veterinary Medicine Hokkaido University
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Ohbayashi Masashi
Department Of Parasitology And Department Of Veterinary Pathology Faculty Of Veterinary Medicine Hok
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Ohbayashi Masashi
Zoonotic Disease Section Arctic Health Research Center U.s. Department Of Health Education And Welfa
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