STUDIES ON EFFECTS OF DRUGS UPON PROTOSCOLECES OF ECHINOCOCCUS GRANULOSUS IN VITRO : I SCOLICIDAL EFFECT OF SALICYLANILIDE AND BISPHENOL DERIVATIVES AGAINST ECH1NOCOCCUS GRANULOSUS IN VITRO

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The protoscoleces of Echinococcus granulosus (BATSCH, 1786) were incubated for ten days in media to which a range of salicylanilide- and bisphenol-derivatives and other compounds were added at the rates of 1,10 and 100γ per ml. The main culture medium was 20% inactivated calf serum with a 1 : 1 mixture of medium 199 and HANKS' solution containing 0.5% lactalbumin hydrolysate and 0.1% yeast extract. The survival rates of the treated and control protoscoleces were compared. Generally, halogenated salicylanilide derivatives showed the highest scolicidal effect and halogenated derivatives of diphenyl sulfide and diphenylmethane ranked next in lethal effect. The intensity of the scolicidal action of salicylanilide derivatives increased with the addition of some halogen atoms. Bisphenol derivatives also showed an increase in scolicidal activity associated with the number of halogen atoms. Descriptions were made of the activity of two types of salicylanilide derivatives and three bisphenol compounds suspended in media with propylene glycol or sodium carboxymethyl cellulose. The drugs in the former manifested a stronger scolicidal effect than in the latter category.
北海道大学の論文