Taenia taeniaeformis larval product induces gastric mucosal hyperplasia in SCID mice
スポンサーリンク
概要
- 論文の詳細を見る
The effects of intraperitoneal implantation of Taenia taeniaeformis larvae and inoculation of in vitro larval products on gastric mucosa of SCID mice were investigated in this study. Mice surgically implanted with T. taeniaeformis larvae developed slight and moderate gastric hyperplasia. When in vitro cultured T. taeniaeformis larval excretory-secretory (TtLES) products containing 1 mg of protein were injected daily into mice, they caused gastropathy after 5-7 days. Mice injected daily with 0.5mg of TtLES products also showed slight gastric hyperplasia after day 14 and 28. The gastropathy was characterized by reduction of both parietal and zymogenic cell number and increased number of alcian blue-periodic acid Schiff (AB-PAS)-positive cells and by twofold extension of proliferative zone of gastric units. Larval implantation demonstrated a more potent effect in inducing gastropathy than did in vitro larval culture products. Significant decrease in number of parietal cells with concomitant increase of proliferative zone and AB-PAS-positive cell number indicated their important roles in inducing the hyperplastic lesion. Similarities with other gastropathies indicated that there is a common fundamental regulatory mechanism involved, and that the host response may not be specific to parasites. Present study validated the induction of gastric mucosal hyperplasia by larval ES products of T. taeniaeformis. This proved the hypothesis of previous studies suggesting the role of larvae-derived products in inducing gastric mucosal hyperplasia in T. taeniaeformis-infected rats.
- 北海道大学の論文
- 2002-02-28
著者
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OKU Yuzaburo
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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Oku Yuzaburo
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Oku Yuzaburo
台湾
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Oku Yuzaburo
北海道大学 獣医学研究科寄生虫学
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NONAKA Nariaki
Laboratory of Parasitology, Graduate School of Veterinary Medicine, Hokkaido University
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KAMIYA Masao
Laboratory of Parasitology, Graduate School of Veterinary Medicine, Hokkaido University
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Kamiya M
Oie Reference Laboratory For Echinococcosis Laboratory Of Environmental Zoology Department Of Biosph
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Kamiya Masao
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Nonaka N
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Lagapa Jose
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Kamiya M
Laboratory Of Environmental Geographic Information System Department Of Biosphere And Environmental
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Nonaka Nariaki
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Lagapa Jose
Department Of Biosphere And Environmental Sciences Faculty Of Environment Systems Oie Reference Labo
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Kamiya Masao
Laboratory Of Environmental Geographic Information System Department Of Biosphere And Environmental
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Oku Yuzaburo
Department Of Animal Disease Control Graduate School Of Veterinary Medicine Hokkaido University
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Oku Y
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Kamiya M
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Oku Y
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Oku Yuzaburo
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Oku Yuzaburo
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine
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Oku Y
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Oku Yuzaburo
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Lagapa Jose
Laboratory of Environmental Zoology, Department of Biosphere and Environmental Sciences, Faculty of Environment System, Rakuno Gakuen University
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