Evaluation of Myanmar Medicinal Plant Extracts for Antitrypanosomal and Cytotoxic Activities
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概要
- 論文の詳細を見る
Current chemotherapeutic options for African trypanosomiasis in humans and livestock are very limited. In the present study, a total of 71 medicinal plant specimens from 60 plant species collected in Myanmar were screened for antitrypanosomal activity against trypomastigotes of Trypanosoma evansi and cytotoxicity against MRC-5 cells in vitro. The methanol extract of dried rootbark of Vitis repens showed the highest antitrypanosomal activity with IC50 value of 8.6 ± 1.5 μg/ml and the highest selectivity index of 24.4. The extracts of Brucea javanica, Vitex arborea, Eucalyptus globulus and Jatropha podagrica had also remarkable activity with IC50 values and selectivity indices in the range of 27.2–52.6 μg/ml and 11.4–15.1, respectively.
著者
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Bawm Saw
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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Tiwananthagorn Saruda
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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Ling Kyaw
Department of Pharmacology and Parasitology, University of Veterinary Science
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HIROTA Junichi
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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IRIE Takao
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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HTUN Lat
Department of Pharmacology and Parasitology, University of Veterinary Science
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MAW Ni
Livestock Breeding and Veterinary Department
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MYAING Tin
Department of Pharmacology and Parasitology, University of Veterinary Science
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PHAY Nyunt
Pathein University
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MIYAZAKI Satoshi
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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SAKURAI Tatsuya
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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OKU Yuzaburo
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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MATSUURA Hideyuki
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture,
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KATAKURA Ken
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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Bawm Saw
北海道大学 獣医学研究科寄生虫学
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Katakura Ken
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Oku Yuzaburo
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Matsuura Hideyuki
Laboratory Of Bio-organic Chemistry Division Of Applied Bioscience Graduate School Of Agriculture Ho
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LIN Kyaw
Department of Pharmacology and Parasitology, University of Veterinary Science
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Oku Yuzaburo
Laboratory Of Parasitology Department Of Disease Control Graduate School Of Veterinary Medicine
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Katakura Ken
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
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HIROTA Junichi
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
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SAKURAI Tatsuya
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
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IRIE Takao
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
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OKU Yuzaburo
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
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