LONGEVITY AND FECUNDITY OF TRICHINELLA SPIRALIS IN MAST CELL-DEFICIENT Sl/Sl^d MICE

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Response to Trichinella spiralis infection in genetically mast cell-deficient Sl/Sl^d mice was studied. Very few or no subepithelial mast cells (SMC) and globule leucocytes (GL) were observed in WCB6F_1-Sl/Sl^d mice in the primary and tertiary infections with T. spiralis. While marked increases of these two cell types were seen in the primary and tertiary infections in their normal littermates. In both primary and tertiary infections delayed expulsion of adult worms from the intestine was seen in Sl/Sl^d mice as compared with that in the normal littermates. In Sl/Sl^d mice the expulsion of worms occurred only slightly faster in the tertirary infection than in the primary infection, whereas in the normal littermates, the expulsion was remarkably faster in the former than in the latter. No difference was noted in the number of muscle larvae recovered from Sl/Sl^d mice and their littermates after intravenous injection of newborn larvae, but greater number of muscle larvae was recovered from Sl/Sl^d mice after oral inoculation of infective muscle larvae. Adult worms obtained from Sl/Sl^d mice showed greater fecundity in vitro than those from the normal litteremates. In both Sl/Sl^d mice and their normal littermates, no significant difference was noted in the production of specific antibodies, as shown by the indirect hemagglutination serum titers and the IgE titers measured by passive cutaneous anaphylaxis reaction. These results suggest a certain positive participation of SMC and GL in the resistance to intestinal phase of T. spiralis infection.
北海道大学の論文
1987-07-31

LONGEVITY AND FECUNDITY OF TRICHINELLA SPIRALIS IN MAST CELL-DEFICIENT Sl/Sl^d MICE

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