<治療に関する研究>脳卒中易発症性高血圧ラット(SHRSP)の生殖および胎児発生におよぼすレセルピン(妊娠9日投与)の影響

概要

論文の詳細を見る
Reserpine, a hypotensive drug, was intramuscularly administered at 0,5,7.5mg/kg to pregnant SHRSP on day 9 of gestation. Maternal weight gain, maternal blood pressure, maternal food intake and maternal water intake were significantly reduced in a dose-dependent manner. At term, the number of implants, litter size and fetal body weight were unaffected. but the number of dead fetuses and incidence of external anomalies were significantly higher in the groups receiving 5 or 7.5mg/kg reserpine compared to those in the controls. As for the external anomalies, only hematoma was observed. These findings showed greater adverse effects compared with those of treatment on day 8 of gestation. Therefore, developmental toxicity of reserpine in SHRSP is influenced by the exposure time.
近畿大学の論文
1994-12-30