<基礎的研究発生病理>E型水迷路試験におけるSHR, SHRSPの学習行動

概要

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The authors investigated the learning ability of SHR, SHRSP and WKY by using the water E maze apparatus. Ten mature male SHR, SHRSP and WKY rats each (16-20 weeks of age ) bred in our laboratory were examined for the water E maze test. The water E maze apparatus was made of plastic E shape tank, each arm being 45cm in length, 15cm in width and 50cm in depth. The maze was filled with 22±2℃ water to a depth of 30cm. A start gate was set at the middle arm of E and an escape ladder (goal) was placed under water at the end of one arm. The water E maze learning test was scheduled for four days with ten trials per day. The swimming time between placement of the test animal into the water and its escape onto the ladder was recorded. Errors were counted as selecting and backing errors. In the swimming time and error counts, there were no significant differences over the all trials among three strains. The errorless performance of SHR, SHRSP and WKY were 69,69 and 60% at day 1,95,90 and 82% at day 2,94,95 and 98% at day 3,and 54,68 and 40% at day 4 (goal reversed), respectively. On day 1 and day 4,the scores of SHR and SHRSP were significantly higher than those of WKY. It is concluded that the learning ability of SHR and SHRSP were better than those of WKY, as indicated by the increase of rats with the errorless performance in this water E maze test system.
近畿大学の論文
1989-12-30