胎生期にアルコールを曝露したSHR仔の行動発達について(I 発生病理)(A 基礎的研究)

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The purpose of this study is to investigate the combined effect of hypertension and alcohol on the behavioral development of rat offspring. SHR and WKY rats were mated overnight. The pregnant rats were intubated with ethanol (ETH, 30%v/v) at 2.4g/kg body weight twice daily throughout pregnancy from day 0 of gestation. The controls were given isocaloric sucrose (SUC) solution and pair-fed with the ETH group. All of the offspring were examined for the following preweaning reflex tests from 4 to 13 days of age : surface righting, cliff avoidance and negative geotaxis. Swimming development was examined between 8 and 21 days of age. After weaning, some of the selected male rats were tested for the post-weaning behavior between 8 and 24 weeks of age : open field, rotarod, underwater T-maze and avoidance conditioning. In the preweaning period, WKY-ETH offspring showed a tendency of slower functional development as measured by the angle score of swimming compared to SUC and this is in agreement with the retarded physical development such as body weight increase and eyelid opening. On the contrary, SHR-ETH offspring did not show significant differences compared to SUC offspring. In the post-weaning period, WKY-ETH females showed significantly lower brain weight. There was no significant ETH effect for any of the measures of behavioral tests in both groups, SHR and WKY, although the strain specific differences in behavior were present between these two strains. Under the present experimental conditions, it may be concluded that some tendency was observed of the reduction in growth and development of the WKY offspring exposed in utero to ethanol but no significant ethanol effects were shown in SHR offspring, which might be due to the complicated interactions between maternal hypertension and ethanol.
近畿大学の論文
1984-12-25

胎生期にアルコールを曝露したSHR仔の行動発達について(I 発生病理)(A 基礎的研究)

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