<基礎的研究発生病理>高血圧自然発症ラット(SHR)の胎仔骨発生に及ぼす塩酸ヒドララジンの影響

概要

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Hydralazine hydrochloride, a hypotensive drug, was given to SHR in drinking water (80ppm) from day 0 to day 21 of pregnancy (group WH) or from 2 weeks before mating until day 21 of pregnancy (group HH). The controls were given tap water only (group WW). The dams were autopsied on day 21 of pregnancy. Average body weight of the fetuses was not significantly different among the three groups. Live fetuses were stained by the cartilage and bone double staining method. The skeletal development of the axial, forelimb and hindlimb skeleton was examined. WH fetuses were significantly retarded in the postlumbar vertebrae, sternebra V, forelimb (proximal phalanges and metacarpal bones) than WW ones. On the other hand, in HH fetuses, the skeletal development was significantly advanced in the sternebra V and forelimb (proximal phalange V) than in WW ones. Retarded ossification was more marked in the lower trunk and posterior extremities in the WH fetuses, while the HH fetuses showed more advanced ossification than the WW fetuses.
近畿大学の論文
1986-12-30