<原著>エタノールのラット母獣および次世代仔に及ぼす影響

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There is much evidence to implicate alcohol as a teratogen in humans. Recently, a variety of animal models has been developed to investigate the effects of prenatal exposure to ethanol, but the results are inconsistent because of the differences in testing procedure and the type of dosing, the period of drug administration and the age of offspring at testing. The present study aims to examine maternal intoxication as well as postnatal growth, activity and learning in their pups by the same route as that humans are exposed. Pregnant Wistar rats were given 5,10,20 and 40% (v/v) ethanol in drinking water and food pellet for 14 days, from day 7 through 20 of gestation. The control group received water and food pellets ad libitum throughout the period of study. Significant inhibition of maternal body weight gain during gestation was observed in the 20% and over ethanol groups and decreases of food and water consumption in all the ethanol groups. Gestation length was significantly prolonged in the 20% ethanol group. The incidence of dams with total litter loss was significantly increased in the 40% ethanol group. Retarded growth of the pups was observed in the 10% and over ethanol groups. At 8 weeks of age, male pups in the 20% ethanol group showed significantly inferior to those of the control in the multiple T-maze water-escape learning test. On the other hand, female pups showed no significant difference from the controls in a two-way shock-avoidance task at 10 weeks of age. A significant decrease in the weight of brain was observed in male pups of the 10% and over ethanol groups. In conclusion, the results obtained indicate that the maternal ethanol drinking ad libitum at specified days of gestation may produce many features of the fetal alcohol effects.
近畿大学の論文
1986-12-25

<原著>エタノールのラット母獣および次世代仔に及ぼす影響

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