高血圧自然発症ラット(SHR)の生殖および胎仔発生に及ぼす塩酸ヒドララジンの影響(I 発生病理)(A 基礎的研究)

概要

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Hydralazine hydrochloride, a hypotensive drug, was given in drinking water (80 ppm) from day 0 of pregnancy until day 21 of pregnancy (group WH) or from 2 weeks before mating until day 21 of pregnancy (group HH). Controls were given tap water only (group WW). The blood pressure of SHR rats was reduced to about 130-140 mmHg in average in groups WH and HH. Maternal body weight was not significantly different among the three groups. At term, no significant differences were observed among the three groups on numbers of corpora lutea, implants, and live fetuses, incidences of the intrauterine death and external malformations, and the fetal body weight. However, the placental weight in groups WH and HH was significantly heavier than that of WW. Histological study of the placentae revealed some degenerative changes such as fibrinoid deposition and cell degeneration both in the basal zone and labyrinth were common to the three groups. The degree of changes was more extensive in groups WH and HH compared with WW. Thus, it is suggested that hydralazine hydrochloride increases the lesion of placenta in SHR. No significant differences were observed on fetal and placental findings between groups WH and HH.
近畿大学の論文
1982-12-31