<原著>Enzyme immunoassayを用いた新しいCarcinoembryonic antigen測定法の基礎と臨床的検討

概要

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That carcinoembryonic antigen (CEA) is valuable as the diagnosis marker of malignant tumars, it has been used widely in routine clinical laboratories. The measurement methods of CEA concentrations in blood as the routine laboratories are broadly divided into two categories of Radioimmunoassay-RIA-and Enzyme immunoassay-EIA-, but recently EIA method tends to spread in place of RIA method that is restricted by facilities on treatments. This time we have studied the basic examinations (analytical precisions, correlation with another method and so on) and the clinical assessments (included the determination of normat value) with respect to EIA method which measuring principle is a two step sandwich method based on the solid-phase enzyme immunoassay. In result it was found that this method had high reproducibility, well recoveries, and good correlation with Z-gel RIA method (r=0.896,n=83,y=1.05x-0.478). Furthermore CEA concentrations in blood of various diseases have showed that especially rectal and colon cancers in the digestive tract system gave high values (average 16.07-28.50 ng/ml). The normal value established by this method (X^^-±SD) was 1.17±0.71 ng/ml and the significant difference between both sexes was not in existence.
近畿大学の論文
1982-09-25