<原著>DMH腸発癌におよぼす腸内細菌叢の影響に関する研究(1) : 腸手術の発癌に及ぼす影響, とくに腸内細菌量との関係について

概要

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Male rats of the SD strain were divided into the following four groups and effect of intestinal microflora on DMH-induced cancer was investigated. Group I included 21 rats with total colectomy and ileo-rectal anastomosis, Group II, 19 rats with transposition of an ileal segment into the colon, Group III, 14 rats with transposition of a colonic segment into the ileum, and Group IV, 12 rats without operation. The rats received subcutaneously DMH of 10mg/kg once weekly on the back. The administration commenced on the 1st week of the operation and lasted 16 weeks. They were sacrificed 26 to 36 weeks after the start of the administration. Microflora and histological findings were examined at each segment of the intestine. The incidence of tumor was 90.5% for Group I, 94.7% for Group II, 100% for Group III, and 16.7% for Group IV. The incidence was higher in the groups undergoing operations. Well differentiated adenocarcinoma appeared most frequently accounting for 81.4% of the tumors in Group I, 58.9% in Group II, 57.2% in Group III, and 50.0% in Group IV. The anastomosed sites of the intestine and transposed segments of the organ especially showed high incidence of cancer. As regards the bacterial quantity, the transposed segment of the intestine in Groups II and III presented 10^6/ml of aerobes and 10^7/ml of anaerobes. These bacterial counts were markedly higher than those of the non-operative group, 10^3〜10^4/ml.
近畿大学の論文
1983-03-25