Constitution of calcium channel current in hamster submandibular ganglion neurons

概要

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The submandibular ganglion (SMG) neuron has been well established as the parasympathetic ganglion that innervates the submandibular and sublmgual salivary glands Thus this neuron plays a key role in salivary secretion In a previous study, we reported that SMG possessed T-, L-, N-, P/Q- and R-type voltage-dependent calcium channels (VDCCs) In this study, we analyzed the contribution of the distinct subtypes of VDCCs currents (I_<Ca>) using the whole-cell configuration of the patch clamp technique in SMG neurons In addition, we also investigated the effects of a strong voltage prepulse on the contributions of the subtypes of VDCCs In SMG neuronal I_<Ca> without a prepulse, the mean percentages of L-, N-, P-, Q- and R-type were 39 7, 31 5, 10 6, 7 1 and 7 9% In SMG neuronal I_<Ca> with prepulse, the mean percentages of L-, N-, P-, Q- and R-type were 37 2, 34 0, 14 0, 7 6 and 7 0% Thus, these results showed that SMG possess multiple types of VDCCs and that N- and P-type VDCCs are facilitated by a prepulse in SMG neurons
東京歯科大学の論文