<Originals>Development of Protective Immunity to Hymenolepis nana Infection in Young Mice
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概要
- 論文の詳細を見る
Young ddY mice given their immunizing infection with Hymenolepis nana eggs during 14 days after birth did not develop a full range of protective immunity as evidenced by a successful infection of H. nana larvae after challenge infection. These mice, however, showed some degree of protection since the number of larvae successfully infected in immunized young mice was significantly lower than that infected in age-matched and non-immunized mice. In contrast, mice given the same infection regimen at 17 days of age or later did develop immunity and completely rejected the challenge larvae typically seen in adult mice. It appears that the functional immunological maturity in this host-parasite system develops at about 2 weeks after birth. Mice which were infected repeatedly with H. nana eggs from an early age and which maintained adult worms for prolonged time periods did not develop immunological tolerance that can persist into adult life. This suggests that the failure of young mice to develop immunity following infection at an early age is not due to tolerance but rather due to an incomplete development of immunological competence of the host during the initial exposure period. Histological observations revealed that the intestine of young mice showed little or no histopathological reaction after primary infection. Secondary infection elicited an accelerated inflammatory reactions with an apparent infiltration of mononuclear cells and neutrophils in the lamina propria of the villi and around the infected larvae. These reactions differed from that seen in adult mice in view of the fact that there was no infiltration of eosinophils in the young mice, suggesting that the failure of young mice to become fully resistant to H. nana infection may be due to the lack of some part of the effector mechanisms.
- 近畿大学の論文
- 1982-12-28
著者
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INOUE Tomoyoshi
Department of Parasitology, Kinki University School of Medicine
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MIYAZATO Takashi
Department of Parasitology Kinki University School of Medicine
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Inoue Tomoyoshi
Department Of Parasitology Kinki University School Of Medicine
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FURUKAWA Tadaaki
Department of Parasitology, Kinki University School of Medicine
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Inoue Tomoyoshi
Department Of Cardiovascular Surgery Kinki University School Of Medicine
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Miyazato T
Kinki Univ. School Of Medicine Osaka Jpn
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Furukawa T
Department Of Parasitology Kinki University School Of Medicine
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Furukawa Tadaaki
Department Of Parasitology Kinki University School Of Medicine
関連論文
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- Development of Protective Immunity to Hymenolepis nana Infection in Young Mice
- Comparison of Protective Immunity against Hymenolepis nana Infection in Mice Immunized by Oral Egg Infection, Oral Cysticercoid Infection and Subcutaneous Egg Injection
- Electron Microscopic Observations on the Penetration of Oncospheres of Hymenolepis nana into the Intestine of the Mouse
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