<Originals>Peripheral blood eosinophilia in mice with Hymenolepis nana infection

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Peripheral blood eosinophilia was induced in male ddY mice following oral infection with Hymenolepis nana eggs. In chronically infected mice, peripheral eosinophil levels reached a peak value during 2 or 3 weeks after primary infection and remained elevated with intermittent fluctuations throughout the observation period. There was a considerable variation in eosinophil levels during the chronic phase of the response. When once-infected mice were challenged with eggs, the abrupt increases in the eosinophil levels occurred 4 days after challenge infection and the cell counts markedly fluctuated for the next few weeks. A distinctive eosinophilic response with a single peak was observed in the mice treated with the oral administration of an anticestode drug, praziquantel, after primary infection. The response in these mice was initiated within a week after infection, reached a peak 2 weeks after infection and then rapidly declined thereafter. There was no further increase in the eosinophil levels. The challenge infection in infected and medicated mice caused a sharp transient rise and fall in the eosinophil levels, the peak response being attained 4 days after challenge infection. These results suggest that the erratic waves of eosinophilic response in chronically infected mice may come from a stimulation of eosinopoiesis due to autoinfection or accidental contamination of eggs of a second generation, although direct effect of adult worms is not ruled out. The dual patterns of eosinophil responses in the mice infected with eggs and challenged after drug treatment suggest that the eosinophil participates in two reactions ; one occurring after primary infection in response to tissue dwelling stage of the worm, and the other being directed against challenge oncosphere larvae in immunized mice. These results are quite compatible with the histopathological observations so far reported and are suggestive of the fact that the peripheral eosinophilia is a reflection of local response of the cell at the infection sites.
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<Originals>Peripheral blood eosinophilia in mice with Hymenolepis nana infection

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