<Originals>Comparison of Protective Immunity against Hymenolepis nana Infection in Mice Immunized by Oral Egg Infection, Oral Cysticercoid Infection and Subcutaneous Egg Injection

概要

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The oral infection of Hymenolepis nana eggs stimulated a strong protective immunity in mice against the oral challenge infection with the eggs of this tapeworm. In contrast, when no autoinfection occurred, an initial cysticercoid infection did not induce protective immunity to challenge egg infection. The artificial immunization with a single subcutaneous injection with 2,000 viable and shell-removed eggs conferred a partial protection to oral egg infection given 3 to 10 weeks after the immunizing injection. Increasing in the number of eggs used for a immunizing injection up to 20,000 eggs per mouse or additional egg doses with 2 spaced injections did not reinforce the protective potency of the immunized mice. Immunity induced by these methods was slower in developing and was only partially efficient as compared with that evoked by oral egg infection. The protective immunity induced by initial subcutaneous egg injection was not effective in preventing the development of the larvae derived from secondary subcutaneous injection of eggs. The subcutaneous injection of deep frozen eggs or formalized eggs was of no value in stimulating the protective immunity.
近畿大学の論文
1979-06-28