<Originals>Histopathological Studies of Mice Actively and Passively Immunized with Hymenolepis nana

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The intestinal histopathological changes of male ddY mice after primary and secondary infections with Hymenolepis nana eggs were examined by histological technique. In primary infection, a gradual increase in the infiltration of eosinophils was noted in the intestinal villi invaded by the larvae from 48 hours after infection. The eosinophilic response peaked at 96 hours after infection when the larvae developed into mature cysticercoid stage. In secondary infection, a rapid onset of eosinophilic response was noted around the invaded larvae as early as 6 hours after challenge infection. This reaction peaked at 24 and 36 hours after challenge infection and diminished quickly thereafter coincidentally with the disappearance of challenge larvae from the tissue. The hematological studies revealed that the peripheral blood eosinophilia in the immunized mice peaked 7 days after challenge infection, while the number of absolute white blood cells was not markedly affected. The specific antibody of IgG class to the crude egg antigen, which was determined by the micro-ELISA method, was detected in the mouse sera 2 weeks after primary infection, and high level of antibody activity was observed at 3,4,and 5 weeks of infection. Normal mice passively immunized by intraperitoneal injection of antisera became highly protective against the oral egg challenge. These mice showed little local and systemic eosinophilic response after challenge infection. It was concluded that the eosinophil was not indispensable for the effective killing of oncospheres in the immunized mice. The hypersensitivity reaction at the infection sites in immunized and challenged mice caused damage to the architecture of the infected villi. It was suggested that the breakdown of the villi might have a role in the clearance of challenge larvae from the tissue of immunized mice.
近畿大学の論文
1984-12-28

<Originals>Histopathological Studies of Mice Actively and Passively Immunized with Hymenolepis nana

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