Characterization of NikA Histidine Kinase and Two Response Regulators with Special Reference to Osmotic Adaptation and Asexual Development in Aspergillus nidulans

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概要

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• Aspergillus nidulans has many histidine-to-aspartate (His-Asp) phosphorelay components, including 15 histidine kinases (HKs), four response regulators (RRs), and a histidine-containing phosphotransfer intermediate (HPt). Of these, NikA (HK) is highly conserved in many filamentous fungi. It has been found that NikA is responsible for the responses of filamentous fungi to fungicides such as iprodione and fludioxonil. Two RRs, SskA and SrrA, are also involved in the fungicide response, providing a typical example of the His-Asp phosphorelay system, in which NikA functions as a sensor upstream of SskA and SrrA in response to fungicides. To gain further insight into the physiological roles of the NikA-SskA/SrrA phosphorelay system, we constructed a pair of ΔnikAΔsskA and ΔnikAΔsrrA double mutants. Here we provide evidence regarding the crucial involvement of the NikA-SskA/SrrA phosphorelay system in both osmotic adaptation and asexual development, including conidia formation. Based on these results, a general insight into the A. nidulans His-Asp phosphorelay network is also discussed.

• 社団法人 日本農芸化学会の論文
• 2009-07-23

著者

• MIZUNO Takeshi

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Mizuno Takeshi

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Mizuno Takeshi

  Lab. Of Molecular Microbiology School Of Agriculture Nagoya Univ.

• Mizuno T

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Mizuno T

  Lab. Of Molecular Microbiology School Of Agriculture Nagoya Univ.

• MIZUNO Takeshi

  School of Agriculture, Nagoya University

• Abe Keietsu

  New Ind. Creation Hatchery Center Tohoku Univ.

• Moritz Thomas

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Abe Keietsu

  Laboratory Of Enzymology Department Of Molecular And Cell Biology Graduate School Of Agricultural Sc

• HAGIWARA Daisuke

  New Industry Creation Hatchery Center, Tohoku University

• Takeuchi Michio

  Department Of Applied Molecular Biology And Biochemistry Tokyo University Of Agriculture And Technol

• Hagiwara Daisuke

  New Industry Creation Hatchery Center Tohoku University

• Mizuno Takeshi

  Laboratory Of Microbiology School Of Agriculture Nagoya University

• Mizuno T

  Faculty Of Agriculture Tokyo University Of Agriculture And Technology

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