Immunohistochemical analysis of osteoconductivity of β-tricalcium phosphate and carbonate apatite applied in femoral and parietal bone defects in rats
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概要
- 論文の詳細を見る
The feature of osteoconductivity, and expression of inductive BMP and transcription factors (Runx2 and Osterix) for osteoblast differentiation, which was related to conductive bone formation, were observed in experimentally created defects in rat femoral and parietal bones filled with β-tricalcium phosphate (β-TCP) or carbonate apatite (CAP). Femoral cortical bone defects were repaired by conductive bone formed by osteoblasts differentiated around β-TCP and CAP, and immunohistochemical observation revealed that the osteoblasts expressed BMPs, Runx2, and Osterix. However, the repair in parietal bone defects was incomplete despite the β-TCP and CAP filling. Only cells, which differentiated around β-TCP or CAP, and formed conductive bone expressed BMPs, Runx2, and Osterix. These findings revealed that the osteoconductivity of calcium phosphate materials required the expression of BMPs as the prerequisite for Runx2 and Osterix expression. Therefore, it is suggested that when calcium phosphate ceramics are used as bone substitute materials, BMPs are essential for osteoconductivity.
- 日本歯科理工学会の論文
- 2009-09-01
著者
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今泉 佳宣
朝日大学歯学部附属村上記念病院一般外科学分野整形外科学分野
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Nakazawa Junko
Department Of Orthopedic Surgery Murakami Memorial Hospital Asahi University
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TAKEUCHI Hiroshi
Division of Thermonuclear Fusion Research,Tokai Establishment,Japan Atomic Energy Research Institute
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KUSAKA YOSHIAKI
Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine
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NAGAYAMA Motohiko
Division of Oral Pathology, Department of Oral Pathogenesis and Disease Control, Asahi University Sc
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IMAIZUMI Yoshinori
Department of Orthopedic Surgery, Murakami Memorial Hospital, Asahi University
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TSUKAHARA Takashi
Department of Orthopedic Surgery, Murakami Memorial Hospital, Asahi University
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OHTOMO Katsuyuki
Department of Orthopedic Surgery, Murakami Memorial Hospital, Asahi University
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Tsukahara Takashi
Department Of Orthopedic Surgery Murakami Memorial Hospital Asahi University
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Tsukahara Takashi
Department Of Electronics Faculty Of Engineering Osaka University
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Kusaka Yoshiaki
Department Of Orthopedic Surgery Murakami Memorial Hospital Asahi University
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Kusaka Yoshiaki
Department Of Orthopaedic Surgery Kyoto Prefectural University Of Medicine
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Ohtomo Katsuyuki
Department Of Orthopedic Surgery Murakami Memorial Hospital Asahi University
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Nagayama Motohiko
Division Of Oral Pathology Department Of Oral Pathogenesis And Disease Control Asahi University Scho
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Imaizumi Yoshinori
Department Of Orthopedic Surgery Murakami Memorial Hospital Asahi University
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Takeuchi Hiroshi
Division Of Thermonuclear Fusion Research Japan Atomic Energy Research Institute Tokai Establishment
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Takeuchi Hiroshi
Division Of Oral Pathology Department Of Oral Pathogenesis And Disease Control Asahi University School Of Dentistry
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Takeuchi Hiroshi
Division Of Chemistry Graduate School Of Science Hokkaido University
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TSUKAHARA Takashi
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University
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