α-Difluoromethylornithine Increases the Anti-tumor Effect of cis-Diamminedichloroplatinum in G-XII Rat Glioma
スポンサーリンク
概要
- 論文の詳細を見る
The in vivo effects of the single or combined administration of α-difluoromethylornithine (DFMO), an inhibitor of polyamine synthesis, and cis-diamminedichloroplatinum (cisplatin) on the growth of G-XII glioma cells inoculated subcutaneously in rats were tested. Treatment with DFMO or cisplatin significantly decreased the bromodeoxyuridine (BrdU) labeling index of tumor tissues. Combined treatment with DFMO and cisplatin achieved a further significant decrease in the BrdU labeling index. All treatments significantly reduced the tissue levels of N^1-acetylspermidine and putrescine, and the ornithine decarboxylase (ODC) activity, but little affected the tissue levels of spermidine and spermine, and the activity of spermidine/spermine N^1-acetyltransferase. The reduction of ODC activity by cisplatin treatment may be associated with the anti-tumor effect.
- 日本脳神経外科学会の論文
- 1995-04-15
著者
-
Tamura Masaru
Departments Of Neurosurgery Gunma University School Of Medicine
-
Sugimoto Hiroyuki
Department Of Surgery Ii Nagoya University Graduate School Of Medicine
-
KURIHARA Hideyuki
Department of Marine Bioresources Chemistry, Faculty of Fisheries, Hokkaido University
-
TSUKAHARA Takashi
Department of Orthopedic Surgery, Murakami Memorial Hospital, Asahi University
-
YAMAZAKI Hiromichi
Department of Neurosurgery, Yamanashi Prefectural Central Hospital
-
Kurihara Hideyuki
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
-
Tamura Masaru
Department Of Environmental Chemistry Faculty Of Engineering Utsunomiya University
-
MATSUZAKI Shigeru
Department of Biochemistry, Dokkyo University School of Medicine
-
Sugimoto Hiroyuki
Department Of Cardiology Hirai Hospital
-
Sugimoto Hiroyuki
Departments Of Biochemistry Gunma University School Of Medicine
-
Tsukahara Takashi
Department Of Electronics Faculty Of Engineering Osaka University
-
Tsukahara Takashi
Departments Of Neurosurgery Gunma University School Of Medicine
-
Yamazaki Hiromichi
Departments Of Neurosurgery Gunma University School Of Medicine
-
Yamazaki Hiromichi
Department Of Neurosurgery Yamanashi Prefectural Central Hospital
-
Matsuzaki Shigeru
Department Of Biochemistry Dokkyo University School Of Medicine
-
TSUKAHARA Takashi
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University
-
Tamura Masaru
Department of Biology, Faculty of Science, Yamagata University
関連論文
- Nonfunctioning neuroendocrine pancreatic tumors : our experience and management
- Is pancreaticogastrostomy safer than pancreaticojejunostomy?
- Metachronous double cancer of the gallbladder and common bile duct
- Cystic Lymphangioma of the Gallbladder : Report of a Case
- Early detection of liver failure after hepatectomy by indocyanine green elimination rate measured by pulse dye-densitometry
- Extended Radical Resection Versus Standard Resection for Pancreatic Cancer : The Rationale for Extended Radical Resection
- Qualitative and Quantitative Analysis of Portal Doppler Waveform and a Novel Factor of Portal Pulsatility : Systolic Spike Wave
- Cullen's Sign in Pancreatic Trauma
- Reversal of portal flow after acute rejection in living-donor liver transplantation
- Delayed Rupture of a Pseudoaneurysm Following Pancreatoduodenectomy : Report of a Case
- Reversal of Portal Blood Flow after Hepatic Resection : Evaluation with Doppler Ultrasonography
- Pulse Doppler Evaluation of Postoperative Liver Function in Living-related Partial Liver Transplantation
- Inhibitory Potencies of Bromophenols from Rhodomelaceae Algae against α-Glucosidase Activity
- Antibacterial Activity against Cariogenic Bacteria and Inhibition of Insoluble Glucan Production by Free Fatty Acids Obtained from Dried Gloiopeltis furcata
- Enamel bonding of self-etching and phosphoric acid-etching orthodontic adhesives in simulated clinical conditions : Debonding force and enamel surface
- Dual Gradient-echo In-phase and Opposed-phase Magnetic Resonance Imaging to Evaluate Lipomatous Metaplasia in Patients with Old Myocardial Infarction
- Correlation between glioblastoma cell infiltration and T2 prolongation on magnetic resonance imaging
- Diagnosis and Treatment of Brainstem Abscess Using Magnetic Resonance Imaging and Microsurgical Aspiration : Case Report
- Small Gliomas: Metabolism and Blood Flow
- Small Gliomas: Clinicopathological Study
- Intraoperative Fluorescence Detection of Malignant Gliomas Using 5-Aminolevulinic Acid
- Central neurocytoma with unusually intense FDG uptake : Case report
- Isolation and Identification of α-Glucosidase Inhibitors from Tochu-cha (Eucommia Ulmoides)
- Geraniin, a Hydrolyzable Tannin from Nymphaea tetragona Georgi (Nymphaeaceae)
- Digalactosyldiacylglycerol Suppression of Inhibition by Sulfoquinovosyldiacylglycerol of α-Glucosidase
- Immunohistochemical analysis of osteoconductivity of β-tricalcium phosphate and carbonate apatite applied in femoral and parietal bone defects in rats
- Granulomatous Angiitis of the Central Nervous System : Case Report
- Low Temperature Magnetic Properties of Organic Radical Magnet, MOTMP
- Studies of the Hydrous Titanium Oxide Ion Exchanger. VII. Effects of pH at Precipitation on the Isotopic Exchange Rate of Na^+ and Cs^+ Ions between the Exchanger in the Relevant Ionic Form and Aqueous Solutions
- Studies of the Hydrous Titanium Oxide Ion Exchanger. IV. Rate of the Isotopic Exchange of Sodium Ions between the Exchanger in the Na^+ Form and Aqueous Solution
- Relationship between Resistance to Bacterial Wilt and Nutrient Uptake in Tomato Seedlings
- Effects of Cationic Surfactants on Settling Properties of Sewage Activated Sludge
- メソポーラス活性炭素繊維の電気二重層容量
- α-Difluoromethylornithine Increases the Anti-tumor Effect of cis-Diamminedichloroplatinum in G-XII Rat Glioma
- Pathological Anatomy of Autopsy Brain with Malignant Glioma
- (-)-ε-Viniferin and Related Oligostilbenes from Carex pumila Thunb. (Cyperaceae)(Organic Chemistry)
- Effect of Calcium Concentration in Nutrient Solution on Development of Bacterial Wilt and Population of Its Pathogen Ralstonia solanacearum in Grafted Tomato Seedlings
- Calcium Uptake and Resistance to Bacterial Wilt of Mutually Grafted Tomato Seedlings
- Effect of Calcium Concentration in Nutrient Solution before and after Inoculation with Ralstonia solanacearum on Resistance of Tomato Seedlings to Bacterial Wilt
- Cerebrospinal Fluid Placental Alkaline Phosphatase in the Intracranial Germinomas:Results of Enzyme Antigen Immunoassay
- Magneto-Impurity Resonance in n-Type Germanium
- Magnetophonon Resonance in n-Type Germanium at Low Temperatures
- A-47. Morphological Studies on the Methylnitrosourea Induced Tumors of the Nerve Roots and Peripheral Nerve
- Clinicopathological Study of Brain Tumor Radiotherapy
- Evaluation of Diagnostic and Operative Problems in Basal Meningioma by Two-plane CT and Angiography : with Special Reference to Operative Indications
- SYNTHESES AND ANALYSES OF A SERIES OF LINEAR PENTAAMINES EXPECTED IN NATURAL SOURCES
- Acute Basilar Artery Occlusion in a Patient With Left Subclavian Artery Occlusion Due to First Rib Anomaly
- Pancreatic head resection with segmental duodenectomy for pancreatic neoplasms
- Reduction of 5-Nucleotidase Activity in Rat Thyroid and Adenohypophysis following Methylthiouracil Treatment
- Changes in Lactate Dehydrogenase Isozyme Patterns of Rat Anterior Pituitary in Varied Thyroid States
- DIFFERENCE IN EFFECTS OF THYROIDECTOMY AND THYROXINE SUPPLEMENT ON HEPATIC AND ANTERIOR PITUITARY ENZYMES IN THE RAT
- Effects of Graded Doses of L-Thyroxine on 14C-Leucine Incorporation into Anterior Pituitary Proteins of Thyroidectomized Rats
- Effects of Thyroidectomy and Thyroxine Supplement on the Glucose Metabolism in the Rat Anterior Pituitary
- Thyroid Function and Polyamines II. Thyrotropin Stimulation of Polyamine Biosynthesis in the Rat Thyroid
- Effect of Cold Exposure on Amino Acid Transport and Incorporation into Rat Anterior Pituitary in vitro
- IN VIVO METABOLISM OF IODOTYROSINES IN THYROIDECTOMIZED RATS
- A Possible Role of Cadaverine in the Biosynthesis of Polyamines in the Japanese Newt Testis
- Thyroid Function and Polyamines III. Changes in Ornithine Decarboxylase Activity and Polyamine Contents in the Rat Thyroid during Hyperplasia and Involution
- Establishment of in vitro spermatogenesis from spermatocytes in the medaka, Oryzias latipes
- Diamine and Polyamine Levels in Spontaneous Skin Papillomas of the Japanese Newt, Cynops pyrrhogaster(COMMUNICATION)(Biochemistry)
- Effect of the Concentration of Metal Ions on their Adsorption on Various Hydrous Iron and Aluminum Oxides
- PS-027-2 The role of antiangiogenic treatment with bevacizumab in combination with oncolytic herpes virus hrR3 in pancreatic cancer
- Primary Intraventricular Meningioma of the Fourth Ventricle : Case Report
- Thyroid Function and Polyamines I. Rapid Fluctuation of Thyroid Ornithine Decarboxylase Activity in Response to Change in Circulating Thyrotropin Level in the Rat
- Contrast-enhanced endoscopic ultrasonography in digestive diseases
- Significant Improvement of Photovoltaic Performance of Dye-sensitized Solar Cells by Using 4-Trimethylsilylpyridine as Organic Additive to Electrolyte Solution
- Studies of the hydrous tin(IV) oxide ion exchanger. V. The sodium isotopic exchange rate between the exchanger in the Na+ form and aqueous solutions.
- The high-temperature reaction of iron with sulfur dioxide.
- Ion-exchange properties and thermal stability of hydrous titanium(VI)-zirconium(IV) oxide ion exchanger.
- Studies of the hydrous niobium(V) oxide ion exchanger. II. Affinity for various cations.
- Olfactory Neuroblastoma with Nasal and Suprasellar Extension: A Case Report.
- Ion-exchange property and thermal stability of hydrous metal oxide ion exchangers.
- Studies of the hydrous niobium(V) oxide ion exchanger. IV. The rate of the isotopic exchange of sodium ions between the exchanger in the Na+ form and aqueous solutions.
- Studies of the hydrous silicon-titanium(IV) oxide ion exchanger. II. Affinity for various cations and thermal stability.
- Studies of hydrous tin(IV) oxide ion-exchangers. I. A method for synthesis and some properties.
- Studies of the Hydrous Zirconium(IV) Oxide Ion Exchanger. II. The Rate of Isotopic Exchange of Sodium Ions between the Exchanger in the Na+ Form and Aqueous Solutions.
- Studies of the hydrous tin(IV) oxide ion exchanger. IV. The effect of heat treatment.
- Studies of a hydrous tin(IV) oxide ion exchanger. VI. Rate of the isotopic exchange of cobalt ions between the exchanger in the cobalt form and aqueous solutions.
- Studies of the hydrous titanium oxide ion exchanger. V. The stability of the hydrogen form in air.
- Studies of the hydrous niobium(V) oxide ion exchanger. III. The effect of heat treatment.
- Effects of H2-Receptor Antagonist on the Cellular Function of Gastric Mucosa in the Rat.
- Effect of heat treatment of hydrous metal oxides on their cation-exchange selectivity.
- Studies of the hydrous niobium(V) oxide ion exchanger. V. Effect of heat treatment on the sodium isotopic exchange rates between hydrous niobium(V) oxide in Na+ form and aqueous solutions.
- Studies on the hydrous niobium(V) oxide ion exchanger. I. A method for synthesis and some properties.
- Studies of the hydrous silicon(IV)-titanium(IV) oxide ion exchanger. I. A method of synthesis and some properties.