DIFFERENCE IN EFFECTS OF THYROIDECTOMY AND THYROXINE SUPPLEMENT ON HEPATIC AND ANTERIOR PITUITARY ENZYMES IN THE RAT
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概要
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Activities of NADPH-cytochrome c reductase, NADPH-dichlorophenolindophenol diaphorase and glucose-6-phosphate dehydrogenase in the anterior pituitary and in the liver were compared in normal and in thyroidectomized rats, with or without thyroxine (T<SUB>4</SUB>) supplement. Responses of pituitary enzymes to thyroidectomy and T<SUB>4</SUB> supplement were different from, in some cases even opposite to, those of the same liver enzymes. The typical response was observed in glucose-6-phosphate dehydrogenase; the enzyme activity in the pituitary increased by thyroidectomy and the increased activity was suppressed by T<SUB>4</SUB> supplement, whereas the activity in the liver decreased by thyroidectomy and increased by T<SUB>4</SUB> treatment. The mechanisms and the physiological significance of these findings were discussed in connection with protein synthesis in the two tissues.
- 社団法人 日本内分泌学会の論文
著者
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MATSUZAKI Shigeru
Department of Biochemistry, Dokkyo University School of Medicine
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Matsuzaki Shigeru
Department Of Biochemistry Dokkyo University School Of Medicine
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