Thyroid Function and Polyamines III. Changes in Ornithine Decarboxylase Activity and Polyamine Contents in the Rat Thyroid during Hyperplasia and Involution
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概要
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Changes in ornithine decarboxylase (ODC) activity and in polyamine contents of the rat thyroid were studied under various experimental conditions. Methylthiouracil (MTU) treatment produced several-fold increases in the thyroid ODC activity and in the content of putrescine, spermidine and spermine within a week. While serum thyrotropin (TSH) levels increased gradually up to 3 weeks, the content of both putrescine and spermidine tended to reach a plateau after 2 weeks of the goitrogen treatment; spermine content continued to increase progressively for 3 weeks. Discontinuance of MTU at 7 days resulted in a rapid decline in the elevated thyroid ODC activity, followed by a diminution of putrescine, spermidine and RNA contents. Thyroidal putrescine, spermidine and RNA responded more sensitively to both introduction and withdrawal of TSH stimulation than thyroidal spermine and DNA.<BR>Excess iodide, having no effect on the basal level of thyroid ODC, suppressed the MTU-induced increase in this enzyme activity without affecting circulating TSH, thyroxine (T<SUB>4</SUB>) and triiodothyronine (T<SUB>3</SUB>) levels. There was a significant negative correlation between the ODC activity and intrathyroidal concentration of iodine in MTUpretreated rats. Theophylline increased the thyroid weight and ODC activity when given to rats fed with a subeffective dose of MTU. Analyses of serum TSH, T<SUB>4</SUB>, T<SUB>3</SUB> and of thyroidal iodine revealed that TSH-induced thyroid ODC activity was suppressed by increased circulating thyroid hormones and/or intrathyroidal iodine. Furthermore, it was suggested that thyroid hormones and excess iodide acted directly on the thyroid to alter polyamine biosynthesis, possibly by changing the responsiveness of the gland to TSH.
- 社団法人 日本内分泌学会の論文
著者
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Suzuki Mitsuo
Department Of Obstetrics And Gynecology Showa University School Of Medicine
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MATSUZAKI Shigeru
Department of Biochemistry, Dokkyo University School of Medicine
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KAKEGAWA TADAO
Department of Physiology, Institute of Endocrinology, Gunma University
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HAMANA KOEI
Protein Chemistry, Institute of Endocrinology, Gunma University
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Matsuzaki Shigeru
Department Of Biochemistry Dokkyo University School Of Medicine
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Suzuki Mitsuo
Department Of Biology College Of Liberal Arts Kanazawa University
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KAKEGAWA TADAO
Departments of Physiology Institute of Endocrinology, Gunma University
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