原因不確定の急性肝障害における Hepatitis E virus 感染の有無の検討

概要

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We have seen 25 cases of etiology-obscure acute liver injury from January 2004 through December 2007 in our hospital, among which 22 cases could be subjected to a retrospective investigation for hepatitis E virus (HEV) infection since their sera had been cryopreserved. As a result, 2 (9.1%) of the 22 cases were positive for both IgM and IgA anti-HEV antibodies (as well as for HEV RNA in one case), suggesting HEV infection as the cause of their liver injuries. Notably, 1 of the 2 cases had been misdiagnosed as "drug-induced hepatitis" (another one as "etiology-unknown hepatitis"). These results warrant implementation of HEV testing as a routine one in primary care settings or city hospitals like ours.
社団法人　日本肝臓学会の論文
2009-03-25