タイ出張後に発症し抗体陽転が遅延し且つ分離株塩基配列がギリシャ・スペイン株に近似していた日本人E型肝炎の1例

概要

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This case of hepatitis E was interesting in the following points. 1) Although thought as an imported infection from Thailand, this case had shorter or longer incubation period for that, and had an HEV genotype which is rare in Thailand. 2) Domestic infection was thought then, but the HEV isolate from the patient was more homologous to Greece/Spain isolates than to Japanese strains. 3) Response of antibodies to HEV was delayed than in usual cases. Also noteworthy was that a highly increased level of the serum 2-5 OAS suggested strongly that the hepatitis in this patient would be virus-origin. But for the finding, we would not have tried to test HEV RNA in the absence of antibodies to HEV.
2005-05-25