Production of Spherical Agglomerates of Cephalosporin Antibiotic Crystals
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概要
- 論文の詳細を見る
A cephalosporin antibiotic, PATC (5-Amino-2-[((6R,7R)-7-{(2Z)-2-(5-amino-1,2,4- thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetylamino}-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-(2-hydroxyethyl)-1H-pyrazol-2-iumchloride; MW 632.1 Da), was crystallized by neutralization method, and the spherical agglomeration of micro crystals was obtained to develop a drug for injection. The morphology of agglomerates depended on the initial super-saturation ratio and the presence or absence of seed crystals. Spherical agglomerates were obtained by adding seed crystals of 0.1 wt% under a high initial super-saturation ratio of 130. The compactly packed spherical agglomerates were composed of a number of rod-shape crystals with a uniform length of 60 μm, and had good filtration property. The specific volume of spherical agglomerates was 1.75 cm3/g.
- 社団法人 化学工学会の論文
- 2008-11-01
著者
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Ooshima Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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Ooshima Hiroshi
Department Of Applied And Bioapplied Chemistry Graduate School Of Engineering Osaka City University
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Koga Keiichi
Chemical Development Laboratories Fujisawa Pharmaceutical Co. Ltd.
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MACHIYA Koji
Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City Unive
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MUKUTA Takashi
Process Chemistry Laboratories, Astellas Pharma Inc.
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MORIKI Shigeru
Chemical Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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KAGARA Kooji
Chemical Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Machiya Koji
Dep. Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univ.
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Machiya Koji
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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Mukuta Takashi
Process Chemistry Laboratories Astellas Pharma Inc.
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Moriki Shigeru
Chemical Development Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Ooshima Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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