Planar Microfluidic System Based on Electrophoresis for Detection of 130-nm Magnetic Labels for Biosensing
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概要
- 論文の詳細を見る
Superparamagnetic beads (SPBs) used as magnetic labels offer potential for the realization of high sensitivity and low cost biosensors for point of care treatment (POCT). For better biomolecular affinity and higher sensitivity, it is desirable to use sub-200-nm-diameter SPBs comparable in size to actual biomolecules. However, the detection of small concentrations of such SPBs by magnetoresistive devices is extremely challenging due to small magnetic response of SPBs. As a solution to these limitations, we describe a simple detecting procedure where the capture of micro-SPBs by immobilized nano-target SPBs due to self-assembly induced by an external magnetic field, which was monitored under an optical microscope. Here we describe biosensing system based on self-assembly of micro-SPBs by nanoSPBs targets using a system without external pumps, thereby enabling greater miniaturization and portability.
- 2011-04-25
著者
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Sandhu Adarsh
Department Of Electrical And Electronic Engineering Tokai University
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Morimoto Yoshitaka
Department Of Applied Chemistry Faculty Of Engineering Osaka Institute Of Technology
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Takamura Tsukasa
Department of Electrical and Electric Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152-8552, Japan
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Takamura Tsukasa
Department of Electrical and Electronic Engineering, Tokyo Institute of Technology, Meguro, Tokyo 152-8552, Japan
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Morimoto Yoshitaka
Department of Electrical and Electronic Engineering, Tokyo Institute of Technology, Meguro, Tokyo 152-8552, Japan
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