Semipermeable Membrane Dressings Can be Used with the Nicotine Transdermal System and Do Not Interfere with Nicotine Absorption
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概要
- 論文の詳細を見る
Objective Adverse skin reactions as a local side effect of nicotine patches sometimes interfere with smoking cessation therapy. We studied the effects of semipermeable membrane dressings (SMD) used under nicotine patches (NP) on nicotine absorption, as assessed according to the urinary cotinine levels, and skin symptoms. Methods First, the urinary cotinine levels were compared in eight nonsmokers that applied NP over SMD and NP without SMD (Study 1). The urinary cotinine levels were measured using a highly sensitive competitive enzyme immunoassay. Second, 28 subjects undergoing NP therapy for diagnosed nicotine dependence were randomly assigned into two groups in a crossover design to receive NP over SMD and NP without SMD. The urinary cotinine levels and skin symptoms were compared between the two treatment groups. During the follow-up period of 48 weeks, the smoking cessation rate was evaluated (Study 2). Results No statistical differences were observed in the urinary cotinine levels between the NP over SMD and NP without SMD groups. In Study 2, the skin symptoms improved with the use of SMD in 42.8% (6/14) of the patients and worsened in 28.5% (4/14) of the patients. No serious skin disorders were reported. The subjects followed in Study 2 exhibited smoking cessation rates of 92.8%, 78.5% and 64.2% at 12, 24 and 48 weeks, respectively. Conclusion The use of NP over SMD is a safe and effective alternative application to NP treatment for preventing the skin symptoms caused by NP without interfering with nicotine absorption.
- 社団法人 日本内科学会の論文
著者
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OHTA Mitsuhiro
Department of Applied Chemistry, Muroran Institute of Technology
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Kobayashi Kazuyuki
Division Of Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of
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Yamamoto Masatsugu
Division Of Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of
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Nishimura Yoshihiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Ohta Mitsuhiro
Department of Medical Biochemistry, Kobe Pharmaceutical University, Japan
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Hazeki Nobuko
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Hospital, Japan
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Shinke Haruko
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Hospital, Japan
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