The Effect of Heavy Metals on Nicotinamide N-methyltransferase Activity In Vitro Relating to Parkinson's Disease
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概要
- 論文の詳細を見る
Objective: The aims of this study were to determine the effects of heavy metals such as manganese on nicotinamide N-methyltransferase (EC 2.1.1.1) (NNMT) activity and to consider the possibility of involvement of NNMT activation in the pathogenesis of heavy metal induced Parkinson’s disease. Methods: NNMT activity in supernatants separated from brain, liver and kidney homogenates of 5 elderly male Wistar rats by centrifugation were measured by high performance liquid chromatography system with fluorescence. NNMT activity under the conditon of 0.5 or 5.0 mM Mn2+, Fe2+, Cu2+ or Cd2+ was compared with control (no metal ion existence). Results: NNMT activities in rat brain, liver and kidneys were significantly decreased by Cu2+, and those in the liver and kidneys were significantly decreased by Cd2+. Mn2+ reduced NNMT activity only in the liver. Fe2+ had no effect on NNMT activity. Conclusions: No metal increased NNMT activity in this study, contrary to our hypothesis. Further study is needed to clarify the reason why the effects of Mn2+ and Fe2+ which have a high relevance to Parkinson’s disease on NNMT activity differ from those of Cu2+ and Cd2+.
- 日本衛生学会の論文
- 2005-07-01
著者
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Maeda Takafumi
Toto
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Maeda Takafumi
Department Of Hygiene & Preventive Medicine Fuskushima Medical University
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Maeda Takafumi
Hokkaido University
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Fukushima Tetsuhito
Department of Hygiene and Preventive Medicine, Fukushima Medical University
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Sugawara Akiko
Department of Hygiene and Preventive Medicine, Fukushima Medical University School of Medicine
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Fukushima Tetsuhito
Department Of Hygiene And Preventive Medicine Fukushima Medical University
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Sugawara Akiko
Department Of Hygiene And Preventive Medicine Fukushima Medical University School Of Medicine:health
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Sugawara Akiko
福島県立医科大学 衛生学
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Maeda Takafumi
Fukushima Medical University
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Maeda Takafumi
Department Of Hygiene And Preventive Medicine Fuskushima Medical University School Of Medicine
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Tanaka Kazuko
Fukushima Medical University
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Maeda Takafumi
I) Department Of Hygiene Preventive Medicine Fukushima Medical University
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OHTA Mitsuhiro
Department of Applied Chemistry, Muroran Institute of Technology
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TANAKA Kazuko
Department of Hygiene and Preventive Medicine, Fukushima Medical University School of Medicine
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YOKOYAMA Hiroko
Department of Clinical Laboratory Medicine, Fukushima Medical University Hospital
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Ohta Mitsuhiro
Department Of Hygiene And Preventive Medicine Fukushima Medical University School Of Medicine
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Maeda T
Fukushima Medical Univ. Jpn
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Tanaka Kazuko
Department Of Hygiene And Preventive Medicine Fukushima Medical University School Of Medicine
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Maeda Takafumi
福島県立医科大学 衛生学講座
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Sato Akihiko
Dept. Hygiene & Preventive Medicine Fukushima Medical University
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Fukushima Tetsuhito
Department Of Hygiene &preventive Medicine Fukushima Medical University School Of Medicine
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Yokoyama Hiroko
Department Of Hygiene And Preventive Medicine School Of Medicine Fukushima Medical University
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Maeda Takafumi
Department Of Biology Faculty Of Science Shinshu University
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Tanaka Kazuko
Department Of Geography Faculty Of Letters Kyoto University
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Fukushima Tetuhito
Department Of Hygiene & Preventive Medicine Fukushima Medical University School Of Medicine
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FUKUSHIMA TETSUHITO
Department of Hygiene & Preventive Medicine, Fukushima Medical University School of Medicine
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