Error and Individual Difference in Cardiovascular Responses to Orthostatic Stress in Humans

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概要

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• Variations in cardiovascular responses to orthostatic stress were investigated in terms of physiological polymorphism. Variations of physiological measurements are subdivided into individual differences and measurement errors. However, individual differences are often considered to be an error in statistical analysis due to its limitations in experimental design. In order to discuss about the relative contribution of individual difference in cardiovascular responses to postural changes, percent contribution (PC) was estimated using the Taguchi method. Six healthy male adults (age range : 21-27) were subjected to orthostatic stress by inducing a postural inclination of 60° head-up-tilting to the horizontal, and the responses were measured thrice in each subject on different days. The respective changes of heart rate (HR) and stroke volume (SV) in the period from the resting supine to the head-up-tilt position were significantly increased (p<0.01) and decreased (p<0.01) without affecting the mean blood pressure (MBP). The PC of individual difference in HR showed a significantly higher ratio of individual difference during the head-up-tilt (71.4-76.2%) compared with supine rest (0.0-50.4%). While the main variations of HR during supine rest were not the individual differences between the subjects, the day-to-day differences within the subject were significant. The PC of individual differences in MBP and SV constantly displayed a significant difference between the subjects. These results suggest that the strategy for maintaining stable cardiovascular regulation may be different even in normal subjects. In the perspective of physiological parameters, PC monitoring may serve as an empirical approach to evaluate physiological polymorphism.

• 日本生理人類学会の論文

著者

• Maeda Takafumi

  Toto

• Maeda Takafumi

  Department Of Hygiene & Preventive Medicine Fuskushima Medical University

• Maeda Takafumi

  Department Of Hygiene And Preventive Medicine Fukushima Medical University

• Ishibashi Keita

  Department of Human Living System Design, Faculty of Design, Kyushu University

• Higuchi Shigekazu

  Japan National Institute of Occupational Safety and Health

• ISHIBASHI Keita

  Faculty of Design, Kyushu University

• HIGUCHI Shigekazu

  Department of Public Health, Akita University School of Medicine

• YASUKOUCHI Akira

  Department of Physiological Anthropology, Faculty of Design, Kyushu University

• Yasukouchi Akira

  Faculty Of Design Kyushu University

• Yasukouchi Akira

  東亜大学 人間科学部

• Yasukouchi Akira

  Department Of Human Living System Design Faculty Of Design Kyushu University

• Higuchi Shigekazu

  福島県立医科大学 衛生学講座

• Maeda Takafumi

  Fukushima Medical University

• Maeda Takafumi

  Department Of Hygiene And Preventive Medicine Fuskushima Medical University School Of Medicine

• Maeda Takafumi

  Department Of Hygiene & Preventive Medicine Fukushima Medical University

• Yasukouchi A

  Faculty Of Design Kyushu University

• Yasukouchi Akira

  Fac. Of Design Kyushu Univ.

• Yasukouchi Akira

  Department Of Physiological Anthropology Kyushu University Of Design Sciences

• Ishibashi Keita

  Fac. Of Design Kyushu Univ.

• Ishibashi Keita

  Department Of Ergonomics Kyushu Institute Of Design

• Higuchi Shigekazu

  Department Of Physiological Anthropology Kyushu University Of Design Sciences

• Higuchi Shigekazu

  Department Of Physiologicai Anthropology Kyushu University Of Oesign Sciences

• Ishibashi Keita

  Department Of Human Living System Design Faculty Of Design Kyushu University

• Yasukouchi A

  Kyushu Univ.

• Maeda Takafumi

  Department Of Biology Faculty Of Science Shinshu University

• Ishibashi Keita

  Department Of Physiological Anthropology Kyushu Institute Of Desigin

• Yasukouchi Akira

  Depariment Of Physiological Anthropology. Kyushu University Of Desgin Sciences

• Higuchi Shigekazu

  Department Of Human Science Faculty Of Design Kyushu University

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