Relationship Between Bronchial Hyperreactivity and Symptoms of Cardiac Asthma in Patients With Non-Valvular Left Ventricular Failure
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概要
- 論文の詳細を見る
To determine whether a relationship exists between bronchial hyperreactiviity and cardiac asthma, which is commonly observed in patients with left heart failure, a methacholine inhalation test was performed in 15 patients with stable left ventricular failure (LVF) and 10 normal subjects. The subjects were divided into 3 groups based on symptoms of nocturnal coughing and/or wheezing in acute exacerbation of LVF. Group A consisted of 8 patients with nocturnal coughing and/or wheezing, Group B consisted of 7 patients without such symptoms, and Group C consisted of the 10 age-matched normal controls. Eleven of the 15 patients with LVF showed a significant increase in respiratory resistance in the methacholine inhalation test, as opposed to none of the normal subjects. The median cumulative dose which produced a 35% decrease in respiratory conductance (PD_<35>Grs) was significantly lower in Group A than in Group B(1.45 log units and 1.90 log units, respectively, p<0 05). The results of pulmonary function tests were not significantly different between Groups A and B. The minimum cumulative dose required to initiate a decrease in respiratory conductance from the baseline, as an index of bronchial sensitivity to methacholine, was significantly correlated with DLCO/VA (r=0.710, p<0.01). We conelude that bronchial hyperreactivity is responsible for cardiac asthma and that it might be related to pulmonary interstitial changes in stable patients with nonvalvular LVF.
- 社団法人日本循環器学会の論文
- 1996-11-20
著者
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Yokoyama Mitsuhiro
First Department Of Internal Medicine Kobe University School Of Medicine
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Hashimoto Akinori
First Department Of Internal Medicine Kobe University School Of Medicine
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Nishimura Yoshihiro
First Department of Internal Medicine, Kobe University School of Medicine
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Maeda Hitoshi
First Department of Internal Medicine, Kobe University School of Medicine
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Tanaka Katsuji
First Department of Internal Medicine, Kobe University School of Medicine
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Tanaka Katsuji
First Department Of Internal Medicine Kobe University School Of Medicine
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Yokoyama Mitsuhiro
First Department Of Internal Medicine Kobe University
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Maeda Hitoshi
First Department Of Internal Medicine Kobe University School Of Medicine
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Nishimura Yoshihiro
Division Of Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of
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Nishimura Yoshihiro
The Department Of Medicine Takatsuki General Hospital
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Nishimura Yoshihiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Nishimura Yoshihiro
Division Of Respiratory Disease Takatsuki General Hospital
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Yokoyama Mitsuhiro
First Department Of Internal Medicine
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