Sphingosine 1-phosphate Induces Alpha-smooth Muscle Actin Expression in Lung Fibroblasts via Rho-kinase
スポンサーリンク
概要
- 論文の詳細を見る
Transformation of fibroblasts into myofibroblasts is an important phenomenon that contributes to airway remodeling in bronchial asthma. Although several articles have recently indicated that a bioactive lysosphingolipid sphingosine 1-phosphate (S1P) plays roles in the pathogenesis of bronchial asthma, the role of S1P in the remodeling process is poorly understood. In the present study, we examined the effects of S1P on alpha-smooth muscle actin (SMA) expression and the morphology in lung fibroblasts. S1P stimulated the expression of alpha-SMA in a human lung fibroblast cell line WI38 that expresses EDG/S1P receptors. These processes were inhibited by Y-27632, but not by pertussis toxin. These results suggest that S1P induces a phenotypic change of lung fibroblasts via Rho-kinase that may lead to airway remodeling.
- 神戸大学の論文
著者
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YOKOYAMA MITSUHIRO
Kobe University, School of Medicine, First Department of Internal Medicine
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Nishimura Yoshihiro
Kobe University Graduate School of Medicine
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Yokoyama Mitsuhiro
Kobe Univ. Graduate School Of Medicine
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Hirase Tetsuaki
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Urata Yoshiko
Kobe University Graduate School of Medicine
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Hirase Tetsuaki
Kobe University Graduate School of Medicine
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Yokoyama Mitsuhiro
Division Of Cardiovascular Medicine Kobe University Graduate School Of Medicine
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Nishimura Yoshihiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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