An Open-Label, Prospective Clinical Study to Evaluate the Efficacy of Prophylactic Antibiotics after Diagnostic Bronchoscopy
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概要
- 論文の詳細を見る
The aim of this study was to prospectively examine the effect of prophylactic antibiotic use on the development of respiratory infections and on the worsening of symptoms after diagnostic fiberoptic bronchoscopy procedures. This study was an open-label, multicenter, controlled, clinical trial. Patients were alternately assigned to a group given prophylactic antibiotics after bronchoscopy (prophylaxis(+) group) and a group not given antibiotic prophylaxis after bronchoscopy (prophylaxis(-) group), and they were followed-up for 1 week. 158 patients were assigned to the prophylaxis(-) group and 153 to the prophylaxis(+) group. Therapeutic antibiotic administration was needed in 3 patients (1.90%) in the prophylaxis(-) group and 5 patients (3.27%) in the prophylaxis(+) group (risk ratio 1.014, 95% confidence interval 0.978-1.052; p=0.446). Worsening of symptoms after bronchoscopy occurred in 57.6% of all patients by day 7, but no significant differences were observed between the 2 study groups. Prophylactic antibiotic use after bronchoscopy did not prevent the development of infectious events and worsening of symptoms, suggesting that prophylactic antibiotics might not be necessary for routine diagnostic bronchoscopic procedures.
- 神戸大学の論文
- 2012-00-00
著者
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Ishikawa Yumiko
Division Of Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of
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Okuno Keiko
Department Of Internal Medicine National Hospital Organization Kobe Medical Center
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Funada Yasuhiro
Division Of Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of
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Takenaka Kazuhiro
Department Of Electronic Engineering Faculty Of Engineering Tohoku University
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Kotani Yoshikazu
Division Of Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of
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Sakashita Akihiro
Division Of Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of
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Kobayashi Kazuyuki
Division Of Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of
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Yamamoto Masatsugu
Division Of Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of
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Nishimura Yoshihiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Funada Yasuhiro
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
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KOTANI Yoshikazu
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
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Sakashita Akihiro
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
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Okuno Keiko
Department of Internal Medicine, Kasai Municipal Hospital
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Takenaka Kazuhiro
Department of Respiratory Disease, Takatsuki General Hospital
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Nagano Tatsuya
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
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Nakata Kyosuke
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
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Kobayashi Kazuyuki
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
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