Consumption of Vitamin B6 Reduces Fecal Ratio of Lithocholic Acid to Deoxycholic Acid, a Risk Factor for Colon Cancer, in Rats Fed a High-Fat Diet
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概要
- 論文の詳細を見る
To examine the effect of supplemental dietary vitamin B6 on the colonic luminal environment, growing male rats were fed a high-fat diet containing 1, 7, or 35 mg pyridoxine HCl/kg diet for 6 wk. Food intake and growth were unaffected by the dietary treatment. Supplemental dietary vitamin B6 significantly reduced the production of a fecal secondary bile acid, lithocholic acid (the most toxic secondary bile acid and a risk factor for colon cancer), and markedly reduced the ratio of lithocholic acid to deoxycholic acid (a less toxic secondary bile acid) in feces (p<0.05). Increasing dietary vitamin B6 increased fecal mucin levels (a marker of intestinal barrier function) in a dose-dependent manner (p<0.05) but did not affect fecal immunoglobulin A levels (an index of intestinal immune function). Cecal levels of organic acids were not significantly affected by supplemental dietary vitamin B6. These results suggest the possibility that dietary vitamin B6 affects the colonic luminal environment by altering the production of secondary bile acids and mucins.
- 財団法人 学会誌刊行センターの論文
著者
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Okazaki Yukako
Faculty Of Human Life Sciences Fuji Women's University
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Kato Norihisa
Graduate School Of Biosphere Sci. Hiroshima Univ.
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Yanaka Noriyuki
Graduate School Of Biosphere Science Hiroshima University
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Sakaguchi Ei
Graduate School Of Natural Science And Technology Okayama University
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Tomotake Hiroyuki
Iida Women's Junior College
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KATO Norihisa
Graduate School of Biosphere Science, Hiroshima University
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SAKAGUCHI Ei
Graduate School of Natural Science and Technology, Okayama University
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UTAMA Zaki
Graduate School of Biosphere Science, Hiroshima University
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SUIDASARI Sofya
Graduate School of Biosphere Science, Hiroshima University
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ZHANG Peipei
Graduate School of Biosphere Science, Hiroshima University
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